TargetView™

Introducing a new generation of advanced data processing software for mass spectrometry

TargetView™: Compound identification using chemometric data analysis

TargetView has been developed by ALMSCO for enhanced processing of data produced by mass spectrometry (MS) to identify the presence of specific target compounds with a sample.

TargetView incorporates ClearView to minimise non-compound specific background ion contributions within a MS data file for enhanced peak integration and to improve compound spectral purity enabling more accurate identification. TargetView then uses the chemometric technique of principle component analysis (PCA) to identify the most charateristic mass fragmentation ions of all the compounds in the data file including the background which it subsequently defines and stores as a class file.

After sample analysis the target compound MIF pattern is searched against this class file for comparison. The matching coefficients are then calculated and a plot of coefficient value with respect to chromatographic retention time (RT) drawn. New compound MIF patterns (.msp format) are easily imported into the Target Spectra directory from the NIST database or from a user library. TargetView currently supports Agilent Technologies (.d) Chemstation files and ALMSCO BenchTOF-dx (.lsc) files.

TargetView of Freon 113 in ambient air at 50 ppt


TargetView analysis has advantages over using extracted ion because the determination is made between the mass fragment pattern of the reference to that of each spectra recorded in the analysis. TargetView, therefore, operated entirely independently of retention time and is not influenced by column type, column age or changes in GC conditions.