ClearView™: GC/MS data reprocessing software
 Improving the GC/MS analysis of trace compounds
ClearView software uses sophisticated Dynamic Background Compensation (DBC) algorithms to distinguish between chromatographic peaks and GC-background/baseline anomalies. It reprocesses stored GC/MS data files, eliminating background ions from the total ion chromatogram (TIC) and improving both spectral purity and peak integration.
The software is fast, intuitive and works on most standard GC/MS data file formats. Files can be processed individually or as a batch for optimum efficiency. Processing takes about 3 seconds per file and none of the original GC/MS data/information is lost.
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ClearView - Summary of main advantages
- Enhances automatic identification of trace target analytes and unknowns in complex samples
- Selectively eliminates interference – flattening baselines, simplifying integration and improving sensitivity
- Simpler integration helps improve quantitative accuracy and run-to-run reproducibility
- ClearView processing is purely additive - original GC/MS data files remain intact and uncompromised
- Reduces costs and boosts lab throughput
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Eliminating system and sample background
GC column bleed, ‘humps’ of unresolved sample matrix, extended solvent ‘tails’ and air ingress can all contribute to the background response, compromising both spectral purity and peak integration accuracy. ClearView provides an innovative solution:
ClearView: Improving compound identification
The following three figures illustrate the effect of high GC/MS background on compound identification and how this is addressed using ClearView.
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TD-GC/MS analysis of landfill gas, showing extreme column bleed. Original TIC data shown (black) together with ClearView reprocessed data (blue) |
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Automatic analysis of the original GC/MS data file does not correctly identify the trace component at 16.486 minutes because high level background ions interfere with the mass ion fragmentation (MIF) pattern |
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Automatic analysis of the ClearView reprocessed data file shows greatly enhanced spectral purity allowing automatic identification of this trace component as thiophene |
ClearView: ClearView; Enhancing sensitivity
By minimising GC/MS background ion contributions ClearView reduces noise and increases sensitivity in full scan mode. In the above example, thiophene has a S/N ratio of approx. 3.0 (RMS) in the original GC/MS data file versus a S/N of /Administration30 in the ClearView reprocessed data file. This is a significant increase in sensitivity.
ClearView: Enhancing quantitative accuracy and repeatability
By minimising GC/MS background ion contributions, ClearView provides a flatter baseline facilitating more accurate and repeatable automatic integration. Furthermore, it does this without compromising any of the mass ions contributing to the chromatographic peak.
ClearView: Enhancing and de-skilling GC/MS productivity
By reducing the need for time-consuming manual re-integration of complex total ion chromatograms by skilled GCMS technicians, ClearView simultaneously improves data quality and lab productivity for minimal cost.
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